The A4136 in Lydbrook is currently closed following a multi-vehicle collision this afternoon (Thursday, March 27).
Police were called shortly before 1pm with a report of a collision involving a lorry and three cars.
There is significant debris on the road and so a closure has been put into place to allow Gloucestershire Highways to clear it.
Motorists are asked to avoid the area and find alternative routes.
Two people have been taken to Gloucester Royal Hospital for treatment.